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1

The Development of a Practical and Reliable Large-Scale Synthesis of 2,6-Diamino-4-bromopyridine

Nettekoven, Matthias, Jenny, Christian

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

2

6-Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds

Röver, Stephan, Andjelkovic, Mirjana, Bénardeau, Agnès, Chaput, Evelyne, Guba, Wolfgang, Hebeisen, Paul, Mohr, Susanne, Nettekoven, Matthias, Obst, Ulrike, Richter, Wolfgang F., Ullmer, Christoph, Wal

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.29 MB

english, 2013

3

Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process

Alanine, Alexander, Nettekoven, Matthias, Roberts, Edward, Thomas, Andrew

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2003

Language:

english

File:

PDF, 400 KB

english, 2003

4

ChemInform Abstract: A Combinatorial Approach Towards 2-Acyl-3-amino-indole Derivatives.

Matthias Nettekoven

Journal:

Year:

2001

File:

PDF, 27 KB

2001

5

ChemInform Abstract: Combinatorial Synthesis of 5-Aryl-[1,2,4]-triazolo-[1,5-a]-pyridine Derivatives as Potential Inhibitors of the Adenosine 2A Receptor.

Matthias Nettekoven

Journal:

Year:

2002

File:

PDF, 32 KB

2002

6

Parallel Iterative Solution-Phase Synthesis of 5-Amino-1-aryl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic Acid Amide Derivatives.

Bernd Brodbeck, Bernd Puellmann, Sebastien Schmitt, Matthias Nettekoven

Journal:

Year:

2003

File:

PDF, 158 KB

2003

7

Synthesis Access to 2-Amido-5-aryl-8-methoxy-triazolopyridine and 2-Amido-5-morpholino-8-methoxy-triazolopyridine Derivatives as Potential Inhibitors of the Adenosine Receptor Subtypes.

Matthias Nettekoven, Bernd Puellmann, Sebastien Schmitt

Journal:

Year:

2003

File:

PDF, 181 KB

2003

8

Comparison of Inhibitory Activity of Isomeric Triazolopyridine Derivatives Towards Adenosine Receptor Subtypes or Do Similar Structures Reveal Similar Bioactivities?

Wolfgang Guba, Matthias Nettekoven, Bernd Puellmann, Claus Riemer, Sebastien Schmitt

Journal:

Year:

2004

File:

PDF, 27 KB

2004

9

Novel and Potent NPY5 Receptor Antagonists Derived from Virtual Screening and Iterative Parallel Chemistry Design.

Wolfgang Guba, Werner Neidhart, Matthias Nettekoven

Journal:

Year:

2005

File:

PDF, 16 KB

2005

10

Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Matthias Nettekoven, Wolfgang Guba, Werner Neidhart, Patrizio Mattei, Philippe Pflieger, Jean-Marc Plancher, Sven Taylor

Journal:

Year:

2006

Language:

english

File:

PDF, 141 KB

english, 2006

11

Synthesis of enantiomerically pure 4-alkylsubstituted tryptophan derivatives by a combination of organometallic reactions with enantioselective enzymatic transformations

Matthias Nettekoven, Manfred Psiorz, Herbert Waldmann

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 229 KB

english, 1995

12

Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Wolfgang Guba, Werner Neidhart, Matthias Nettekoven

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 181 KB

english, 2005

13

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Matthias Nettekoven, Wolfgang Guba, Werner Neidhart, Patrizio Mattei, Philippe Pflieger, Olivier Roche, Sven Taylor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 206 KB

english, 2005

14

Refinement of histamine H3 ligands pharmacophore model leads to a new class of potent and selective naphthalene inverse agonists

Olivier Roche, Matthias Nettekoven, Walter Vifian, Rosa Maria Rodriguez Sarmiento

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 333 KB

english, 2008

15

Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors

Emmanuel Pinard, Daniela Alberati, Edilio Borroni, Holger Fischer, Dominik Hainzl, Synèse Jolidon, Jean-Luc Moreau, Robert Narquizian, Matthias Nettekoven, Roger D. Norcross, Henri Stalder, Andrew W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 197 KB

english, 2008

16

Selective naphthalene H3 receptor inverse agonists with reduced potential to induce phospholipidosis and their quinoline analogs

Rosa María Rodríguez Sarmiento, Matthias H. Nettekoven, Sven Taylor, Jean-Marc Plancher, Hans Richter, Olivier Roche

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.88 MB

english, 2009

17

Rational design of novel pyrrolidine derivatives as orally active neurokinin-3 receptor antagonists

Hassen Ratni, Theresa M. Ballard, Caterina Bissantz, Torsten Hoffmann, Philippe Jablonski, Frederic Knoflach, Henner Knust, Parichehr Malherbe, Matthias Nettekoven, Angelique Patiny-Adam, Claus Riemer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 990 KB

english, 2010

18

A combinatorial approach towards 2-acyl-3-amino-indole derivatives

Matthias Nettekoven

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 79 KB

english, 2000

19

Parallel iterative solution-phase synthesis of 5-amino-1-aryl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid amide derivatives

Bernd Brodbeck, Bernd Püllmann, Sébastien Schmitt, Matthias Nettekoven

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 289 KB

english, 2003

20

Combinatorial synthesis of libraries of indole derivatives

Matthias Nettekoven

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 162 KB

english, 2001

21

Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities?

Wolfgang Guba, Matthias Nettekoven, Bernd Püllmann, Claus Riemer, Sébastien Schmitt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 350 KB

english, 2004

22

5-Hydroxyindole-2-carboxylic Acid Amides: Novel Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity

Pierson, Pascale David, Fettes, Alec, Freichel, Christian, Gatti-McArthur, Silvia, Hertel, Cornelia, Huwyler, Jörg, Mohr, Peter, Nakagawa, Toshito, Nettekoven, Matthias, Plancher, Jean-Marc

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 472 KB

english, 2009

23

Diastereoselective synthesis of an argatroban intermediate, ethyl (2R,4R)-4-methylpipecolate, by means of a Mandyphos/rhodium complex-catalyzed hydrogenation

Patrizia Ferraboschi, Maria De Mieri, Paride Grisenti, Matthias Lotz, Ulrike Nettekoven

Journal:

Tetrahedron: Asymmetry

Year:

2011

Language:

english

File:

PDF, 399 KB

english, 2011

24

Evaluation of a flow-photochemistry platform for the synthesis of compact modules

Matthias Nettekoven, Bernd Püllmann, Rainer E. Martin, David Wechsler

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 656 KB

english, 2012

25

Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

Dr. Diego A. Fort, Dr. Thomas J. Woltering, Dr. Matthias Nettekoven, Dr. Henner Knust, Prof. Dr. Thorsten Bach

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 513 KB

english, 2012

26

Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions

Dr. Diego A. Fort, Dr. Thomas J. Woltering, Dr. Matthias Nettekoven, Dr. Henner Knust, Prof. Dr. Thorsten Bach

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 524 KB

english, 2012

27

Highly potent and selective cannabinoid receptor 2 agonists: Initial hit optimization of an adamantyl hit series identified from high-through-put screening

Nettekoven, Matthias, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Kimbara, Atsushi, Püllmann, Bernd, Rogers-Evans, Mark, Röver, Stephan, Schuler, Franz, Schulz-Gasch, Tanja, Ullmer, Christoph

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 782 KB

english, 2013

28

Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions

Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 1.00 MB

english, 2013

29

Ligand-Based Combinatorial Design of Selective Purinergic Receptor (A 2A ) Antagonists Using Self-Organizing Maps

Schneider, Gisbert, Nettekoven, Matthias

Journal:

Journal of Combinatorial Chemistry

Year:

2003

Language:

english

File:

PDF, 79 KB

english, 2003

30

Identification of a Critical Residue in the Transmembrane Domain 2 of Tachykinin Neurokinin 3 Receptor Affecting the Dissociation Kinetics and Antagonism Mode of Osanetant (SR 142801) and Piperidine-Based Structures

Malherbe, Pari, Kratzeisen, Claudia, Marcuz, Anne, Zenner, Marie-Thérèse, Nettekoven, Matthias H., Ratni, Hasane, Wettstein, Joseph G., Bissantz, Caterina

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.89 MB

english, 2009

31

NEW POLYETHYLENE GLYCOL POLYMERS AS KETAL PROTECTING GROUPS – A POLYMER SUPPORTED APPROACH TO SYMMETRICALLY SUBSTITUTED SPIROKETALS

Haag, Rainer, Leach, Andrew G., Ley, Steven V., Nettekoven, Matthias, Schnaubelt, Jürgen

Journal:

Synthetic Communications

Year:

2001

Language:

english

File:

PDF, 256 KB

english, 2001

32

Combinatorial Synthesis of 5-Aryl-[1,2,4]-triazolo-[1,5-a]-pyridine Derivatives as Potential Inhibitors of the Adenosine 2A Receptor

Nettekoven, Matthias

Journal:

Year:

2001

Language:

english

File:

PDF, 67 KB

english, 2001

33

Synthetic Access to 2-Amido-5-aryl-8-methoxy-triazolopyridineand 2-Amido-5-morpholino-8-methoxy-triazolopyridine Derivativesas Potential Inhibitors of the Adenosine Receptor Subtypes

Nettekoven, Matthias, Püllmann, Bernd, Schmitt, Sébastien

Journal:

Year:

2003

Language:

english

File:

PDF, 79 KB

english, 2003

34

Preface

Nettekoven, Matthias, Thomas, Andrew

Journal:

Current Medicinal Chemistry

Year:

2002

File:

PDF, 39 KB

2002

35

Preface

Nettekoven, Matthias, Thomas, Andrew

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 39 KB

english, 2002

36

Accelerating Drug Discovery by Integrative Implementation of Laboratory Automation in the Work Flow

Nettekoven, Matthias, Thomas, Andrew

Journal:

Current Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 280 KB

english, 2002

37

Lead Generation: Sowing the Seeds for Future Success

Bleicher, Konrad H., Nettekoven, Matthias, Peters, Jens-Uwe, Wyler, René

Journal:

CHIMIA International Journal for Chemistry

Year:

2004

Language:

english

File:

PDF, 1.22 MB

english, 2004

38

Inside Cover: Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases (ChemMedChem 2/2016)

Nettekoven, Matthias, Adam, Jean-Michel, Bendels, Stefanie, Bissantz, Catarina, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Guba, Wolfgang, Kimbara, Atsushi, Ottaviani, Giorgio, Püllmann, Bernd, R

Journal:

Year:

2016

File:

PDF, 1.21 MB

2016

39

ChemInform Abstract: Conformationally Restricted Pyrrolidines by Intramolecular [2 + 2] Photocycloaddition Reactions.

Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten

Journal:

Year:

2013

File:

PDF, 26 KB

2013

40

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Neidhart, Werner, Ackermann, Jean, Amrein, Kurt, Conte, Aurelia, Hunziker, Daniel, Kuhn, Bernd, Märki, Hans Peter, Nettekoven, Matthias, Ruf, Armin, Schulz-Gasch, Tanja, Mayweg, Alexander V.

Journal:

CHIMIA International Journal for Chemistry

Year:

2015

Language:

english

File:

PDF, 982 KB

english, 2015

41

Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series

Pierson, Pascale David, Freichel, Christian, Gatti-Mac Arthur, Silvia, Hertel, Cornelia, Huwyler, Jörg, Mohr, Peter, Nakagawa, Toshito, Nettekoven, Matthias, Plancher, Jean-Marc, Raab, Susanne, Richte

Journal:

CHIMIA International Journal for Chemistry

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

42

Strategies for Accelerating the Development of Catalytic Enantioselective Reactions

Blaser, Hans-Ulrich, Hoge, Garrett, Lotz, Matthias, Nettekoven, Ulrike, Schnyder, Anita, Spindler, Felix

Journal:

CHIMIA International Journal for Chemistry

Year:

2008

Language:

english

File:

PDF, 557 KB

english, 2008

43

Novel Triazolopyrimidine-Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases

Nettekoven, Matthias, Adam, Jean-Michel, Bendels, Stefanie, Bissantz, Catarina, Fingerle, Jürgen, Grether, Uwe, Grüner, Sabine, Guba, Wolfgang, Kimbara, Atsushi, Ottaviani, Giorgio, Püllmann, Bernd, R

Journal:

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

44

ChemInform Abstract: Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2 + 2] Photocycloaddition Reactions.

Fort, Diego A., Woltering, Thomas J., Nettekoven, Matthias, Knust, Henner, Bach, Thorsten

Journal:

Year:

2013

File:

PDF, 31 KB

2013

45

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

Ouali Alami, Najwa, Schurr, Christine, Olde Heuvel, Florian, Tang, Linyun, Li, Qian, Tasdogan, Alpaslan, Kimbara, Atsushi, Nettekoven, Matthias, Ottaviani, Giorgio, Raposo, Catarina, Röver, Stephan, R

Journal:

The EMBO Journal

Year:

2018

Language:

english

File:

PDF, 5.50 MB

english, 2018

46

Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process

Alanine, Alexander, Nettekoven, Matthias, Roberts, Edward, Thomas, Andrew

Journal:

Combinatorial Chemistry & High Throughput Screening

Year:

2003

File:

PDF, 400 KB

2003